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Analysis of factors associated with recurrence in Vogt-Koyanagi-Harada disease

Jeeyun Ahn, MD, PhD


Jeeyun Ahn, Joo Young Shin, Jeong Hyun Lee



Department of Ophthalmology, Seoul National University, College of Medicine

Department of Ophthalmology, Seoul Metropolitan Government Seoul National University Boramae Medical Center

Purpose: This study aimed to identify factors associated with recurrence in patients undergoing treatment for Vogt-Koyanagi-Harada (VKH) disease.

Methods: A retrospective review was conducted on patients treated for VKH with a minimum follow-up period of 6 months. Recurrent cases were identified based on the recurrence of inflammation, and comparative analyses were performed on clinical factors and treatment regimens between recurrent and non-recurrent cases.

Result: A total of 16 patients (30 eyes) were included. At onset, the average age was 50.3 ± 15.0 years, with 56.3% being female. Recurrence occurred in 7 patients (43.8%) at an average of 5.7 ± 4.0 months after the initial presentation. The recurrent group exhibited an older initial age (60.4 ± 7.6 vs. 42.4 ± 14.9 years, p=0.008) and a higher oral steroid dose at 6 months after presentation (14.3 ± 13.4 vs. 2.0 ± 3.5 mg, p=0.016). However, no significant differences were observed between the two groups regarding initial bilateral involvement, initial steroid pulse therapy, usage of immunomodulatory therapy at 6 months, > +2 cells at presentation, systemic symptoms at presentation, and initial visual acuity.

Conclusion: VKH patients with recurrent disease were initially older and had higher dose of oral steroids at 6 months. Predicting VKH recurrence based on clinical factors may be limited.


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