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Correlation between Atrophy Size on Fundus Autofluorescence and Ellipsoid Zone Defect area on OCT Measurements of Geographic Atrophy

Amir Hariri

Presenter:

Amir Hariri, MD, Mohamed Ahmed, MD, Rubbia Afridi, MD, Yasir Sepah, MD, Quan Dong Nguyen, MD

Authors:

Affiliation:

1. OIRRC

2. Byers Eye Institute

Purpose: To evaluate correlation between atrophy size on fundus autofluorescence and ellipsoid zone defect area on OCT measurements of geographic atrophy

Design: Retrospective, cross-sectional study

Participants: Four hundred twenty eyes from 230 subjects with GA associated with age-related macular degeneration.

Methods: Subjects with atrophic age-related macular degeneration who underwent both FAF and SD-OCT (Heidelberg)imaging were included in this retrospective analysis. The borders of all areas of definite decreased autofluorescence (DDAF) corresponding to GA were semi-automatically outlined on FAF images by certified graders at OIRRC using region finder tool. EZ defect was manually delineated on every single b-scan on OCT and a custom-made software generated EZ defect map by interpolating between adjacent b-scans. The fundus autofluorescence and SD-OCT-derived measurements were correlated.

Main Outcome Measures: Correlation between EZ defect and DDAF area measurements.

Results: The mean GA area measured from the FAF images was 4.75 ± 3.44 mm2, compared with an EZ defect area of 4.94 ±3.45 mm2 measured using SD-OCT. There was a significant correlation between these two measurements (r = 0.97; P < 0.001).

Conclusions: Spectral-domain OCT-derived measurements of EZ defect area correlates well with areas of DDAF obtainedfrom FAF images. This observation may support the use of SD-OCT-based measurements of the EZ defect area as a surrogate outcome measure in clinical research and clinical trials

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